HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

The gp120 CD4 binding site (CD4bs) and coreceptor binding site (CoRbs) are two functionally conserved elements of the HIV-1 envelope glycoproteins (Env). We previously defined the presence of CD4bs-neutralizing antibodies in the serum of an HIV-1-infected individual and subsequently isolated the CD4...

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Detalhes bibliográficos
Main Authors: Li, Yuxing, O'Dell, Sijy, Wilson, Richard, Wu, Xueling, Schmidt, Stephen D., Hogerkorp, Carl-Magnus, Louder, Mark K., Longo, Nancy S., Poulsen, Christian, Guenaga, Javier, Chakrabarti, Bimal K., Doria-Rose, Nicole, Roederer, Mario, Connors, Mark, Mascola, John R., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457177/
https://ncbi.nlm.nih.gov/pubmed/22875963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01543-12
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