HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

The gp120 CD4 binding site (CD4bs) and coreceptor binding site (CoRbs) are two functionally conserved elements of the HIV-1 envelope glycoproteins (Env). We previously defined the presence of CD4bs-neutralizing antibodies in the serum of an HIV-1-infected individual and subsequently isolated the CD4...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Li, Yuxing, O'Dell, Sijy, Wilson, Richard, Wu, Xueling, Schmidt, Stephen D., Hogerkorp, Carl-Magnus, Louder, Mark K., Longo, Nancy S., Poulsen, Christian, Guenaga, Javier, Chakrabarti, Bimal K., Doria-Rose, Nicole, Roederer, Mario, Connors, Mark, Mascola, John R., Wyatt, Richard T.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2012
الموضوعات:
Vaccines and Antiviral Agents
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457177/
https://ncbi.nlm.nih.gov/pubmed/22875963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01543-12
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