Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site

The monoclonal antibody (MAb) VRC01 was isolated from a slowly progressing HIV-1-infected donor and was shown to neutralize diverse HIV-1 strains by binding to the conserved CD4 binding site (CD4bs) of gp120. To better understand the virologic factors associated with such antibody development, we ch...

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Bibliographic Details
Main Authors: Wu, Xueling, Wang, Charlene, O'Dell, Sijy, Li, Yuxing, Keele, Brandon F., Yang, Zhongjia, Imamichi, Hiromi, Doria-Rose, Nicole, Hoxie, James A., Connors, Mark, Shaw, George M., Wyatt, Richard T., Mascola, John R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347292/
https://ncbi.nlm.nih.gov/pubmed/22419808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07139-11
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