Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1–infected individuals, but the virologic basis of their neutralization remains poorly understood. We used knowledge of HIV-1 envelope structure to develop antigenically resurfaced glycoproteins specific for the structur...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wu, Xueling, Yang, Zhi-Yong, Li, Yuxing, Hogerkorp, Carl-Magnus, Schief, William R., Seaman, Michael S., Zhou, Tongqing, Schmidt, Stephen D., Wu, Lan, Xu, Ling, Longo, Nancy S., McKee, Krisha, O'Dell, Sijy, Louder, Mark K., Wycuff, Diane L., Feng, Yu, Nason, Martha, Doria-Rose, Nicole, Connors, Mark, Kwong, Peter D., Roederer, Mario, Wyatt, Richard T., Nabel, Gary J., Mascola, John R.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965066/
https://ncbi.nlm.nih.gov/pubmed/20616233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187659
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires