Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1–infected individuals, but the virologic basis of their neutralization remains poorly understood. We used knowledge of HIV-1 envelope structure to develop antigenically resurfaced glycoproteins specific for the structur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Wu, Xueling, Yang, Zhi-Yong, Li, Yuxing, Hogerkorp, Carl-Magnus, Schief, William R., Seaman, Michael S., Zhou, Tongqing, Schmidt, Stephen D., Wu, Lan, Xu, Ling, Longo, Nancy S., McKee, Krisha, O'Dell, Sijy, Louder, Mark K., Wycuff, Diane L., Feng, Yu, Nason, Martha, Doria-Rose, Nicole, Connors, Mark, Kwong, Peter D., Roederer, Mario, Wyatt, Richard T., Nabel, Gary J., Mascola, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965066/
https://ncbi.nlm.nih.gov/pubmed/20616233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187659
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge