HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding s...

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Main Authors: Doria-Rose, Nicole A., Louder, Mark K., Yang, Zhongjia, O'Dell, Sijy, Nason, Martha, Schmidt, Stephen D., McKee, Krisha, Seaman, Michael S., Bailer, Robert T., Mascola, John R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302320/
https://ncbi.nlm.nih.gov/pubmed/22258252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06745-11
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