HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding s...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Doria-Rose, Nicole A., Louder, Mark K., Yang, Zhongjia, O'Dell, Sijy, Nason, Martha, Schmidt, Stephen D., McKee, Krisha, Seaman, Michael S., Bailer, Robert T., Mascola, John R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2012
נושאים:
Vaccines and Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302320/
https://ncbi.nlm.nih.gov/pubmed/22258252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06745-11
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