Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization

The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat HIV-1 infection. Due to the antigenically diverse nature of the HIV-1 envelope (Env), no single antibody is highly active against all viral...

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Vydáno v:J Virol
Hlavní autoři: Asokan, M., Rudicell, R. S., Louder, M., McKee, K., O'Dell, S., Stewart-Jones, G., Wang, K., Xu, L., Chen, X., Choe, M., Chuang, G., Georgiev, I. S., Joyce, M. G., Kirys, T., Ko, S., Pegu, A., Shi, W., Todd, J. P., Yang, Z., Bailer, R. T., Rao, S., Kwong, P. D., Nabel, G. J., Mascola, J. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665248/
https://ncbi.nlm.nih.gov/pubmed/26446600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02097-15
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