Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against cardiovascular disease by largely unknown mechanisms. We tested the hypothesis that EPA and DHA may compete with arachidonic acid (AA) for the conversion by cytochrome P450 (CYP) enzymes, resulting in the formation of alterna...

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Bibliographische Detailangaben
Hauptverfasser: Arnold, Cosima, Markovic, Marija, Blossey, Katrin, Wallukat, Gerd, Fischer, Robert, Dechend, Ralf, Konkel, Anne, von Schacky, Clemens, Luft, Friedrich C., Muller, Dominik N., Rothe, Michael, Schunck, Wolf-Hagen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963419/
https://ncbi.nlm.nih.gov/pubmed/20732876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118406
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