17(R),18(S)-Epoxyeicosatetraenoic Acid, A Potent Eicosapentaenoic Acid (EPA)-Derived Regulator of Cardiomyocyte Contraction: Structure-Activity Relationships and Stable Analogs

17(R),18(S)-Epoxyeicosatetraenoic acid [17(R),18(S)-EETeTr], a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (EPA), exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca(2+)-overload with an EC(50) ~1–2 nM. Structure-activity studies revealed a ci...

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Detalhes bibliográficos
Main Authors: Falck, John R., Wallukat, Gerd, Puli, Narender, Goli, Mohan, Arnold, Cosima, Konkel, Anne, Rothe, Michael, Fischer, Robert, Müller, Dominik N., Schunck, Wolf-Hagen
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122156/
https://ncbi.nlm.nih.gov/pubmed/21591683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200132q
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