Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase

The related RING domain proteins MdmX and Mdm2 are best known for their role as negative regulators of the tumor suppressor p53. However, although Mdm2 functions as a ubiquitin ligase for p53, MdmX does not have appreciable ubiquitin ligase activity. In this study, we performed a mutational analysis...

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Hlavní autoři: Iyappan, Saravanakumar, Wollscheid, Hans-Peter, Rojas-Fernandez, Alejandro, Marquardt, Andreas, Tang, Hao-Cheng, Singh, Rajesh K., Scheffner, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963378/
https://ncbi.nlm.nih.gov/pubmed/20705607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.115113
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