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Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase
The related RING domain proteins MdmX and Mdm2 are best known for their role as negative regulators of the tumor suppressor p53. However, although Mdm2 functions as a ubiquitin ligase for p53, MdmX does not have appreciable ubiquitin ligase activity. In this study, we performed a mutational analysis...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963378/ https://ncbi.nlm.nih.gov/pubmed/20705607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.115113 |
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