MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

Genetic evidence has implicated both Mdm2 and MdmX as essential in negative regulation of p53. However, the exact role of MdmX in this Mdm2-dependent protein degradation is not well understood. Most, if not all, previous Mdm2 studies used GST-Mdm2 fusion proteins in the in vitro assays. Here, we sho...

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Bibliographic Details
Main Authors: Wang, Xinjiang, Wang, Junru, Jiang, Xuejun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129153/
https://ncbi.nlm.nih.gov/pubmed/21572037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213868
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