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MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination
Genetic evidence has implicated both Mdm2 and MdmX as essential in negative regulation of p53. However, the exact role of MdmX in this Mdm2-dependent protein degradation is not well understood. Most, if not all, previous Mdm2 studies used GST-Mdm2 fusion proteins in the in vitro assays. Here, we sho...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129153/ https://ncbi.nlm.nih.gov/pubmed/21572037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213868 |
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