Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53

p53 functions as a critical guardian of the genome, orchestrating tumor suppression pathways and ensuring the integrity of chromosomal stability. Mdm2 and MdmX, homologous proteins, serve as negative feedback regulators of p53. In approximately half of tumor cases, overexpression of Mdm2/MdmX result...

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Manylion Llyfryddiaeth

Prif Awduron:	Qiuyin Wei, Chenqi Li, Yibing Tang, Jinping Bai, Wang Li, Jidong Liu, Zhengding Su, Xiyao Cheng
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2025-04-01
Cyfres:	Biomolecules
Pynciau:	tumor suppressor protein p53 Mdm2 MdmX Lid
Mynediad Ar-lein:	https://www.mdpi.com/2218-273X/15/5/642
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!