Wird geladen...

Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay

E3 ubiquitin ligases are of interest as drug targets for their ability to regulate protein stability and function. The oncogene Mdm2 is an attractive E3 ligase to target, as it is the key negative regulator of the tumor suppressor p53, which controls the transcription of genes involved in cell fate....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Herman, Ariel G., Hayano, Miki, Poyurovsky, Masha V., Shimada, Kenichi, Skouta, Rachid, Prives, Carol, Stockwell, Brent R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353153/
https://ncbi.nlm.nih.gov/pubmed/22586610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0104
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!