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MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress
The activity of the tumor suppressor p53 is tightly controlled by its main negative regulator, Mdm2, which inhibits p53's transcriptional activity and targets it for degradation via the proteasome pathway. The closely related Mdm2 homolog, MdmX, is also considered to be a general inhibitor of t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302446/ https://ncbi.nlm.nih.gov/pubmed/22290440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06150-11 |
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