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MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

The activity of the tumor suppressor p53 is tightly controlled by its main negative regulator, Mdm2, which inhibits p53's transcriptional activity and targets it for degradation via the proteasome pathway. The closely related Mdm2 homolog, MdmX, is also considered to be a general inhibitor of t...

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Main Authors: Biderman, Lynn, Poyurovsky, Masha V., Assia, Yael, Manley, James L., Prives, Carol
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302446/
https://ncbi.nlm.nih.gov/pubmed/22290440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06150-11
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