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MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

The activity of the tumor suppressor p53 is tightly controlled by its main negative regulator, Mdm2, which inhibits p53's transcriptional activity and targets it for degradation via the proteasome pathway. The closely related Mdm2 homolog, MdmX, is also considered to be a general inhibitor of t...

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Main Authors: Biderman, Lynn, Poyurovsky, Masha V., Assia, Yael, Manley, James L., Prives, Carol
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302446/
https://ncbi.nlm.nih.gov/pubmed/22290440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06150-11
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