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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
Mdm2, a key negative regulator of the p53 tumor suppressor, is a RING-type E3 ubiquitin ligase. The Mdm2 RING domain can be biochemically fractionated into two discrete species, one of which exists as higher order oligomers that are visible by electron microscopy, whereas the other is a monomer. Bot...
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1782380/ https://ncbi.nlm.nih.gov/pubmed/17170710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601465 |
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