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Deconstructing nucleotide binding activity of the Mdm2 RING domain
Mdm2, a central negative regulator of the p53 tumor suppressor, possesses a Really Interesting New Gene (RING) domain within its C-terminus. In addition to E3 ubiquitin ligase activity, the Mdm2 RING preferentially binds adenine base nucleotides, and such binding leads to a conformational change in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995081/ https://ncbi.nlm.nih.gov/pubmed/20671028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq669 |
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