Ubiquitin- and MDM2 E3 Ligase-independent Proteasomal Turnover of Nucleostemin in Response to GTP Depletion

Nucleostemin (NS) is a nucleolar GTP-binding protein essential for ribosomal biogenesis, proliferation, and animal embryogenesis. It remains largely unclear how this protein is regulated. While working on its role in suppression of MDM2 and activation of p53, we observed that NS protein (but not mRN...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lo, Dorothy, Dai, Mu-Shui, Sun, Xiao-Xin, Zeng, Shelya X., Lu, Hua
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Protein Synthesis and Degradation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323031/
https://ncbi.nlm.nih.gov/pubmed/22318725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335141
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