A carregar...
MDM2 promotes p21(waf1/cip1) proteasomal turnover independently of ubiquitylation
The CDK inhibitor p21(waf1/cip1) is degraded by a ubiquitin-independent proteolytic pathway. Here, we show that MDM2 mediates this degradation process. Overexpression of wild-type or ring finger-deleted, but not nuclear localization signal (NLS)-deleted, MDM2 decreased p21(waf1/cip1) levels without...
Na minha lista:
| Main Authors: | , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291841/ https://ncbi.nlm.nih.gov/pubmed/14633995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg600 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|