MDM2 promotes p21(waf1/cip1) proteasomal turnover independently of ubiquitylation

The CDK inhibitor p21(waf1/cip1) is degraded by a ubiquitin-independent proteolytic pathway. Here, we show that MDM2 mediates this degradation process. Overexpression of wild-type or ring finger-deleted, but not nuclear localization signal (NLS)-deleted, MDM2 decreased p21(waf1/cip1) levels without...

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Опубликовано в::	EMBO J
Главные авторы:	Jin, Yetao, Lee, Hunjoo, Zeng, Shelya X., Dai, Mu-Shui, Lu, Hua
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2003
Предметы:	Articles
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291841/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14633995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg600
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