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MDM2 promotes p21(waf1/cip1) proteasomal turnover independently of ubiquitylation
The CDK inhibitor p21(waf1/cip1) is degraded by a ubiquitin-independent proteolytic pathway. Here, we show that MDM2 mediates this degradation process. Overexpression of wild-type or ring finger-deleted, but not nuclear localization signal (NLS)-deleted, MDM2 decreased p21(waf1/cip1) levels without...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291841/ https://ncbi.nlm.nih.gov/pubmed/14633995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg600 |
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