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The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates

To maintain protein homeostasis, cells must balance protein synthesis with protein degradation. Accumulation of misfolded or partially degraded proteins can lead to the formation of pathological protein aggregates. Here we report the use of destabilizing domains, proteins whose folding state can be...

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Detalhes bibliográficos
Main Authors: Chu, Bernard W., Kovary, Kyle M., Guillaume, Johan, Chen, Ling-chun, Teruel, Mary N., Wandless, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843071/
https://ncbi.nlm.nih.gov/pubmed/24158444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499350
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