The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates

To maintain protein homeostasis, cells must balance protein synthesis with protein degradation. Accumulation of misfolded or partially degraded proteins can lead to the formation of pathological protein aggregates. Here we report the use of destabilizing domains, proteins whose folding state can be...

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Bibliografski detalji
Glavni autori: Chu, Bernard W., Kovary, Kyle M., Guillaume, Johan, Chen, Ling-chun, Teruel, Mary N., Wandless, Thomas J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Protein Synthesis and Degradation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843071/
https://ncbi.nlm.nih.gov/pubmed/24158444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499350
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