A ubiquitin variant-based affinity approach selectively identifies substrates of the ubiquitin ligase E6AP in complex with HPV-11 E6 or HPV-16 E6

The E6 protein of both mucosal high-risk human papillomaviruses (HPVs) such as HPV-16, which have been causally associated with malignant tumors, and low-risk HPVs such as HPV-11, which cause the development of benign tumors, interacts with the cellular E3 ubiquitin ligase E6-associated protein (E6A...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Ebner, Felix A., Sailer, Carolin, Eichbichler, Daniela, Jansen, Jasmin, Sladewska-Marquardt, Anna, Stengel, Florian, Scheffner, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Protein Synthesis and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606683/
https://ncbi.nlm.nih.gov/pubmed/32855237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015603
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