Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with three different clinical pictures. Hijacking of E6AP by the E6 oncoprotein of distinct human papillomaviruses (HPV) contributes to the development of cervical cancer, whereas loss of...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mortensen, Franziska, Schneider, Daniel, Barbic, Tanja, Sladewska-Marquardt, Anna, Kühnle, Simone, Marx, Andreas, Scheffner, Martin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538620/
https://ncbi.nlm.nih.gov/pubmed/26216987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505923112
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