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Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with three different clinical pictures. Hijacking of E6AP by the E6 oncoprotein of distinct human papillomaviruses (HPV) contributes to the development of cervical cancer, whereas loss of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mortensen, Franziska, Schneider, Daniel, Barbic, Tanja, Sladewska-Marquardt, Anna, Kühnle, Simone, Marx, Andreas, Scheffner, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538620/
https://ncbi.nlm.nih.gov/pubmed/26216987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505923112
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