Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation

High-risk Human papillomaviruses (HPVs) types are associated with more than 90% of premalignant and malignant squamous lesions of the uterine cervix. The E6 oncoprotein of high-risk HPVs is a key determinant in cell transformation because it induces the degradation of the host pro-apoptotic tumor su...

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Bibliografske podrobnosti
izdano v:Front Microbiol
Main Authors: Li, Siying, Hong, Xiaoling, Wei, Zhentong, Xie, Min, Li, Wanying, Liu, Guanchen, Guo, Haoran, Yang, Jiaxin, Wei, Wei, Zhang, Songling
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842930/
https://ncbi.nlm.nih.gov/pubmed/31749782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.02483
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