Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin–proteasome system

The oncogenic human papillomavirus (HPV) E6/E7 proteins are essential for the onset and maintenance of HPV-associated malignancies. Here, we report that activation of the cellular ubiquitin–proteasome system (UPS) by the omega-3 fatty acid, docosahexaenoic acid (DHA), leads to proteasome-mediated de...

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Vydáno v:Cell Death Dis
Hlavní autoři: Jing, K, Shin, S, Jeong, S, Kim, S, Song, K-S, Park, J-H, Heo, J-Y, Seo, K-S, Park, S-K, Kweon, G-R, Wu, T, Park, J-I, Lim, K
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260735/
https://ncbi.nlm.nih.gov/pubmed/25393480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.477
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