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Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex
The human papillomavirus (HPV) oncoprotein E6 specifically binds to E6AP (E6-associated protein), a HECT (homologous to the E6AP C terminus)-type ubiquitin ligase, and directs its ligase activity toward the tumor suppressor p53. To examine the biochemical reaction in vitro, we established an efficie...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791319/ https://ncbi.nlm.nih.gov/pubmed/31492752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008374 |
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