Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex

The human papillomavirus (HPV) oncoprotein E6 specifically binds to E6AP (E6-associated protein), a HECT (homologous to the E6AP C terminus)-type ubiquitin ligase, and directs its ligase activity toward the tumor suppressor p53. To examine the biochemical reaction in vitro, we established an efficie...

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Udgivet i:J Biol Chem
Main Authors: Masuda, Yuji, Saeki, Yasushi, Arai, Naoko, Kawai, Hidehiko, Kukimoto, Iwao, Tanaka, Keiji, Masutani, Chikahide
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791319/
https://ncbi.nlm.nih.gov/pubmed/31492752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008374
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