Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates

Ubiquitin-specific protease 7 (USP7) regulates various cellular pathways through its deubiquitination activity. Despite the identification of a growing number of substrates of USP7, the molecular mechanism by which USP7 removes ubiquitin chains from polyubiquitinated substrates remains unexplored. T...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Masuda, Yuji, Kanao, Rie, Kawai, Hidehiko, Kukimoto, Iwao, Masutani, Chikahide
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422070/
https://ncbi.nlm.nih.gov/pubmed/30647135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005167
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