Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

The p53 pro-apoptotic tumor suppressor is mutated or functionally altered in most cancers. In epithelial tumors induced by “high-risk” mucosal Human Papillomaviruses (hrm-HPVs), including human cervical carcinoma and a growing number of head-and-neck cancers (1), p53 is degraded by the viral oncopro...

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Udgivet i:Nature
Main Authors: Martinez-Zapien, Denise, Ruiz, Francesc Xavier, Poirson, Juline, Mitschler, André, Ramirez-Ramos, Juan, Forster, Anne, Cousido-Siah, Alexandra, Masson, Murielle, Pol, Scott Vande, Podjarny, Alberto, Travé, Gilles, Zanier, Katia
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853763/
https://ncbi.nlm.nih.gov/pubmed/26789255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16481
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