Felis catus papillomavirus type-2 E6 binds to E6AP, promotes E6AP/p53 binding and enhances p53 proteasomal degradation

E6 from high risk human papillomaviruses (HR HPVs) promotes ubiquitination and degradation of p53 tumour suppressor by mediating its binding to ubiquitin ligase E6AP in a ternary complex, contributing to cell transformation in cervical cancer. We have previously shown that Felis catus papillomavirus...

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Publicat a:Sci Rep
Autors principals: Altamura, Gennaro, Power, Karen, Martano, Manuela, degli Uberti, Barbara, Galiero, Giorgio, De Luca, Giovanna, Maiolino, Paola, Borzacchiello, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277439/
https://ncbi.nlm.nih.gov/pubmed/30510267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35723-7
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