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Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.

E6-AP is a 100-kDa cellular protein that mediates the interaction of the human papillomavirus type 16 and 18 E6 proteins with p53. The association of p53 with E6 and E6-AP promotes the specific ubiquitination and subsequent proteolytic degradation of p53 in vitro. We recently isolated a cDNA encodin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell Biol
Egile Nagusiak: Huibregtse, J M, Scheffner, M, Howley, P M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 1993
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360130/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8393140/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4918
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