Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.
E6-AP is a 100-kDa cellular protein that mediates the interaction of the human papillomavirus type 16 and 18 E6 proteins with p53. The association of p53 with E6 and E6-AP promotes the specific ubiquitination and subsequent proteolytic degradation of p53 in vitro. We recently isolated a cDNA encodin...
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| 發表在: | Mol Cell Biol |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
1993
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360130/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8393140/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.8.4918-4927.1993 |
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