The Small Molecule BIBR1532 Exerts Potential Anti-cancer Activities in Preclinical Models of Feline Oral Squamous Cell Carcinoma Through Inhibition of Telomerase Activity and Down-Regulation of TERT

Expression of telomerase reverse transcriptase (TERT) and telomerase activity (TA) is a main feature of cancer, contributing to cell immortalization by causing telomeres dysfunction. BIBR1532 is a potent telomerase inhibitor that showed potential anti-tumor activities in several types of cancer, by...

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Detalhes bibliográficos
Publicado no:Front Vet Sci
Main Authors: Altamura, Gennaro, degli Uberti, Barbara, Galiero, Giorgio, De Luca, Giovanna, Power, Karen, Licenziato, Luca, Maiolino, Paola, Borzacchiello, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Veterinary Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855307/
https://ncbi.nlm.nih.gov/pubmed/33553285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fvets.2020.620776
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