Sensitive detection of Aβ protofibrils by proximity ligation - relevance for Alzheimer's disease

BACKGROUND: Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and p...

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Autores principales: Kamali-Moghaddam, Masood, Pettersson, Frida Ekholm, Wu, Di, Englund, Hillevi, Darmanis, Spyros, Lord, Anna, Tavoosidana, Gholamreza, Sehlin, Dag, Gustafsdottir, Sigrun, Nilsson, Lars NG, Lannfelt, Lars, Landegren, Ulf
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Methodology Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2959092/
https://ncbi.nlm.nih.gov/pubmed/20923550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-124
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