Sensitive detection of Aβ protofibrils by proximity ligation - relevance for Alzheimer's disease

BACKGROUND: Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and p...

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Autori principali: Kamali-Moghaddam, Masood, Pettersson, Frida Ekholm, Wu, Di, Englund, Hillevi, Darmanis, Spyros, Lord, Anna, Tavoosidana, Gholamreza, Sehlin, Dag, Gustafsdottir, Sigrun, Nilsson, Lars NG, Lannfelt, Lars, Landegren, Ulf
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2959092/
https://ncbi.nlm.nih.gov/pubmed/20923550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-124
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