African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA

African swine fever virus (ASFV) encodes an AP endonuclease (pE296R) which is essential for virus growth in swine macrophages. We show here that the DNA repair functions of pE296R (AP endonucleolytic, 3′ → 5′ exonuclease, 3′-diesterase and nucleotide incision repair (NIR) activities) and DNA binding...

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Detalhes bibliográficos
Main Authors: Redrejo-Rodríguez, Modesto, Ishchenko, Alexander A., Saparbaev, Murat K., Salas, María L., Salas, José
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958311/
https://ncbi.nlm.nih.gov/pubmed/19464038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.04.021
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