Genetic and Biochemical Characterization of Human AP Endonuclease 1 Mutants Deficient in Nucleotide Incision Repair Activity

BACKGROUND: Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER pathway, APE1 cleaves DNA at AP sites and 3′-blocking moieties generated by DNA glycosylases. In the NIR path...

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Hauptverfasser: Gelin, Aurore, Redrejo-Rodríguez, Modesto, Laval, Jacques, Fedorova, Olga S., Saparbaev, Murat, Ishchenko, Alexander A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923195/
https://ncbi.nlm.nih.gov/pubmed/20808930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012241
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