New Insights in the Removal of the Hydantoins, Oxidation Product of Pyrimidines, via the Base Excision and Nucleotide Incision Repair Pathways

BACKGROUND: Oxidative damage to DNA, if not repaired, can be both miscoding and blocking. These genetic alterations can lead to mutations and/or cell death, which in turn cause cancer and aging. Oxidized DNA bases are substrates for two overlapping repair pathways: base excision (BER) and nucleotide...

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Main Authors: Redrejo-Rodríguez, Modesto, Saint-Pierre, Christine, Couve, Sophie, Mazouzi, Abdelghani, Ishchenko, Alexander A., Gasparutto, Didier, Saparbaev, Murat
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143120/
https://ncbi.nlm.nih.gov/pubmed/21799731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021039
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