Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells

Spontaneous hydrolytic deamination of cytosine to uracil (U) in DNA is a constant source of genome instability in cells. This mutagenic process is greatly enhanced at high temperatures and in single-stranded DNA. If not repaired, these uracil residues give rise to C→T transitions, which are the most...

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Main Authors: Prorok, Paulina, Alili, Doria, Saint-Pierre, Christine, Gasparutto, Didier, Zharkov, Dmitry O., Ishchenko, Alexander A., Tudek, Barbara, Saparbaev, Murat K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785768/
https://ncbi.nlm.nih.gov/pubmed/24023064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305624110
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