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The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5′-dangling modified nucleotide. This mechanistic feature is distinct from DNA glycosylase-m...

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Detalhes bibliográficos
Main Authors: Gros, Laurent, Ishchenko, Alexander A., Ide, Hiroshi, Elder, Rhoderick H., Saparbaev, Murat K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC373275/
https://ncbi.nlm.nih.gov/pubmed/14704345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh165
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