Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway

BACKGROUND: Oxygen free radicals induce lipid peroxidation (LPO) that damages and breaks polyunsaturated fatty acids in cell membranes. LPO-derived aldehydes and hydroxyalkenals react with DNA leading to the formation of etheno(ε)-bases including 1,N (6)-ethenoadenine (εA) and 3,N (4)-ethenocytosine...

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Main Authors: Prorok, Paulina, Saint-Pierre, Christine, Gasparutto, Didier, Fedorova, Olga S., Ishchenko, Alexander A., Leh, Hervé, Buckle, Malcolm, Tudek, Barbara, Saparbaev, Murat
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522590/
https://ncbi.nlm.nih.gov/pubmed/23251620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051776
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