African Swine Fever Virus Protein pE296R Is a DNA Repair Apurinic/Apyrimidinic Endonuclease Required for Virus Growth in Swine Macrophages

We show here that the African swine fever virus (ASFV) protein pE296R, predicted to be a class II apurinic/apyrimidinic (AP) endonuclease, possesses endonucleolytic activity specific for AP sites. Biochemical characterization of the purified recombinant enzyme indicated that the K(m) and catalytic e...

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Bibliographic Details
Main Authors: Redrejo-Rodríguez, Modesto, García-Escudero, Ramón, Yáñez-Muñoz, Rafael J., Salas, María L., Salas, José
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472066/
https://ncbi.nlm.nih.gov/pubmed/16641276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.10.4847-4857.2006
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