Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7

Toll-like receptor (TLR)-7 agonists show prominent immunostimulatory activities. The synthesis of a TLR7-active N(1)-(4-aminomethyl)benzyl substituted imidazoquinoline 5d served as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. Fluorescence m...

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Bibliografiske detaljer
Main Authors: Shukla, Nikunj M., Mutz, Cole A., Ukani, Rehman, Warshakoon, Hemamali J., Moore, David S., David, Sunil A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957514/
https://ncbi.nlm.nih.gov/pubmed/20933417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.093
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