Toward Self-Adjuvanting Subunit Vaccines: Model Peptide and Protein Antigens Incorporating Covalently Bound Toll-Like Receptor-7 Agonistic Imidazoquinolines

Toll-like receptor (TLR)-7 agonists show prominent Th1-biased immunostimulatory activities. A TLR7-active N(1)-(4-aminomethyl)benzyl substituted imidazoquinoline 1 served as a convenient precursor for the syntheses of isothiocyanate and maleimide derivatives for covalent attachment to free amine and...

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Detalhes bibliográficos
Main Authors: Shukla, Nikunj M., Lewis, Tyler C., Day, Timothy P., Mutz, Cole A., Ukani, Rehman, Hamilton, Chase D., Balakrishna, Rajalakshmi, David, Sunil A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098923/
https://ncbi.nlm.nih.gov/pubmed/21549593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.04.050
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