Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the children’s oncology group

Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar t...

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Detalhes bibliográficos
Main Authors: Pollack, Ian F., Hamilton, Ronald L., Murdoch, Geoffrey H., Burger, Peter C., Brat, Daniel J., Rosenblum, Marc K., Nikiforova, Marina N., Holmes, Emiko J., Zhou, Tianni, Cohen, Kenneth J., Jakacki, Regina I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954435/
https://ncbi.nlm.nih.gov/pubmed/20607350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-010-0297-3
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