Mismatch Repair Deficiency Is an Uncommon Mechanism of Alkylator Resistance in Pediatric Malignant Gliomas: A Report From the Children's Oncology Group

BACKGROUND: Alkylating agents are commonly used in the treatment of childhood malignant gliomas. Overexpression of O(6)-methylguanine-DNA methyltransferase (MGMT)constitutes an important mechanism for resistance to such agents, and MGMT status has been associated with outcome in several recent trial...

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Autori principali: Pollack, Ian F., Hamilton, Ronald L., Sobol, Robert W., Nikiforova, Marina N., Nikiforov, Yuri E., Lyons-Weiler, Maureen A., LaFramboise, William A., Burger, Peter C., Brat, Daniel J., Rosenblum, Marc K., Gilles, Floyd H., Yates, Allan J., Zhou, Tianni, Cohen, Kenneth J., Finlay, Jonathan L., Jakacki, Regina I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036982/
https://ncbi.nlm.nih.gov/pubmed/20589656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22634
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