Mismatch Repair Deficiency Is an Uncommon Mechanism of Alkylator Resistance in Pediatric Malignant Gliomas: A Report From the Children's Oncology Group

BACKGROUND: Alkylating agents are commonly used in the treatment of childhood malignant gliomas. Overexpression of O(6)-methylguanine-DNA methyltransferase (MGMT)constitutes an important mechanism for resistance to such agents, and MGMT status has been associated with outcome in several recent trial...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Pollack, Ian F., Hamilton, Ronald L., Sobol, Robert W., Nikiforova, Marina N., Nikiforov, Yuri E., Lyons-Weiler, Maureen A., LaFramboise, William A., Burger, Peter C., Brat, Daniel J., Rosenblum, Marc K., Gilles, Floyd H., Yates, Allan J., Zhou, Tianni, Cohen, Kenneth J., Finlay, Jonathan L., Jakacki, Regina I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036982/
https://ncbi.nlm.nih.gov/pubmed/20589656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22634
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares