A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples

BACKGROUND: Genomic instability in cancer leads to abnormal genome copy number alterations (CNA) as a mechanism underlying tumorigenesis. Using microarrays and other technologies, tumor CNA are detected by comparing tumor sample CN to normal reference sample CN. While advances in microarray technolo...

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Autori principali: Lisovich, Alex, Chandran, Uma R, Lyons-Weiler, Maureen A, LaFramboise, William A, Brown, Ashley R, Jakacki, Regina I, Pollack, Ian F, Sobol, Robert W
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041647/
https://ncbi.nlm.nih.gov/pubmed/21269491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-4-14
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