Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the children’s oncology group

Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar t...

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Bibliographic Details
Main Authors: Pollack, Ian F., Hamilton, Ronald L., Murdoch, Geoffrey H., Burger, Peter C., Brat, Daniel J., Rosenblum, Marc K., Nikiforova, Marina N., Holmes, Emiko J., Zhou, Tianni, Cohen, Kenneth J., Jakacki, Regina I.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954435/
https://ncbi.nlm.nih.gov/pubmed/20607350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-010-0297-3
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