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Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry
Familial hypertrophic cardiomyopathy (FHC) is caused by mutations in sarcomeric proteins including the myosin regulatory light chain (RLC). Two such FHC mutations, R58Q and N47K, located near the cationic binding site of the RLC, have been identified from population studies. To examine the molecular...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951453/ https://ncbi.nlm.nih.gov/pubmed/20855589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009619107 |
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